Postdoctoral Fellow - Chemical Biology & Ubiquitin Pathway Research

The Christina Woo Lab at the Broad Institute is seeking a highly motivated Postdoctoral Fellow with a strong background in chemical biology, proteomics, and organic chemistry. This position will focus on the development of chemical tools and strategies to investigate E3 ubiquitin ligase pathways, with a particular emphasis on the cereblon (CRBN) complex and its regulation of endogenous substrates.

The successful candidate will join an interdisciplinary team that applies a chemistry-first approach to explore mechanistic and functional aspects of protein regulation through post-translational modification. The lab is particularly interested in applicants who are eager to work at the intersection of chemistry and biology and are excited to develop and apply innovative approaches to complex biological questions.

Responsibilities

• Design and execute research aimed at identifying and characterizing CRBN substrates.
• Develop and apply chemical biology tools to investigate E3 ligase activity.
• Integrate proteomics and targeted biochemical analyses to study substrate profiles.
• Collaborate with lab members and external collaborators across disciplines.
• Present research findings at lab meetings, conferences, and through publications.

Required Qualifications

• Ph.D. in Chemical Biology, Chemistry, Biochemistry, or related field (completed or near completion).
• Strong experience with chemical proteomics, organic synthesis, or protein modification.
• Demonstrated ability to work independently and collaboratively in a research environment.
• Excellent written and oral communication skills.

Preferred Skills

• Experience with protein modification strategies.
• Familiarity with ubiquitin or ubiquitin-like protein pathways.
• Mass spectrometry and proteomic data analysis.
• Experience with chemistry and chemical biology tools.

To Apply

Please submit a CV and a brief cover letter outlining your research experience and interests. Applications will be reviewed on a rolling basis.