Scientist

As a lab-based Scientist/Sr. Scientist in the Complex Models group within the Respiratory, Immunology & Inflammation Biology Unit (RIIBU), you will contribute to the conduct of preclinical in vivo experiments to support drug discovery projects from target validation through to clinical phases. You will have the opportunity to work on targets and in vivo models relevant to respiratory and immune-related diseases.

• Contribute to the implementation and lab/vivarium-based execution of preclinical efficacy and mechanistic in vivo studies to enable PK/PD and translational biomarker data generation using robust study design principles in accordance with GSK principles, written standards and SOPs.

• Have the learning agility to develop a robust understanding of scientific rationales, key objectives, endpoints and Go/No-Go decisions for in vivo studies.

• Design, execute (lab/vivarium), analyze, and present in vivo studies with increasing independence as the In Vivo Leader (IVL) representative on portfolio projects with input from Biology Leader (BL), Project Leader (PL), and Complex Models Leadership Team.

• Understand and apply robust study design (RSD) principles, gain input from SMEs and matrix partners (e.g. LASG, Statistics, PK modelling, Histopathology, Dispensary, Biopharm and Chemistry) prior to seeking endorsement/recommendations for animal studies at Independent Scientific Review (ISR) forum and Pre-Study Briefings (PSB).

• Solve technical issues in experimental planning, setup and execution, either independently or with guidance.

• Lab/vivarium based execution of studies to enable sample/tissue acquisition, processing, and analysis to integrate PK/PD and translational biomarker data from in vivo studies and where necessary utilize advanced ex vivo assay techniques such as Flow cytometry, ELISA's, MSD, Luminex and qPCR.

• Responsible for maintaining technical expertise/competency and confidence in rodent handling, dosing, blood and tissue collection, and measurements of biological/ physiological function (e.g. Organ function, Hemodynamics).

• Be familiar with Federal Laws surrounding animal use in research and the local governance process (IACUC, AUP).

• Be familiar with severity limits/constraints related to adverse effects and respond as required under IACUC, AUP and GSK Policy on Care, Welfare and Treatment of Animals. Key contact for animal studies, including provision of out of hours procedures as required.

• Take responsibility for assessing animal health and welfare, document findings, and act on them or seek expert advice when necessary.

• Work effectively with internal matrix partners (BL, PL) and contribute to external study planning and oversight (e.g. CRO, academic groups), including Study Monitoring responsibilities.

• Maintain accurate, up to date and detailed electronic laboratory records in alignment with data integrity standards and ensure compliance with all relevant written standards, SOPs, Risk Assessments and safety guidelines.

• Foster an enterprise culture of innovation, collaboration, inclusion, and continuous learning.

• Read literature and apply it to in vivo studies.

• BSc in a biological science and 2+ years of in vivo research experience either in industry or an academic environment.

• Lab/vivarium-based working knowledge of animal model systems in Respiratory and/or Immunology.

• Knowledge or experience of ELISA's, MSD, Luminex and qPCR

If you have the following characteristics, it would be a plus:

• Understanding of disease mechanisms and/or immune pathways and/or have the learning agility and ability to develop this knowledge.

• Knowledge of robust study design (RSD) principles and experience of critiquing protocols.

• Knowledge of flow cytometry (standard and spectral)

• Extensive experience of rodent handling, dosing, tissue necropsy, and blood sampling including familiarity of IT systems to maintain accurate records, e.g.: Tick@Lab, eLN, PACT.

• Thorough understanding of animal welfare and 3Rs and use of this knowledge to balance study design to achieve scientific objectives.

• Demonstrate problem-solving skills during planning and in-life phase and have the ability or learning agility to critically analyse in vivo data using appropriate data visualization software and statistical methods (e.g. demonstrate proficiency with GraphPad Prism and Spotfire).

• Can work independently as well as collaboratively in a team-oriented environment.

• Good written and verbal communication skills within the line and matrix teams including proficiency in Microsoft Office, Teams, and Sharepoint.

• May have the ability to contribute to the oversight (as Study Monitor) of external animal studies conducted at CRO or academic groups.

• Demonstrate flexibility to manage multiple studies in distinct phases of experimental conduct.

• Awareness and application of risk assessments and SOPs and local safety practices to ensure a safe working environment.

• Keep up to date with the relevant literature and be able to write and critique scientific documents and be able to communicate scientific ideas and findings, both verbally and in written form to internal teams.

• Demonstrate learning agility.

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