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Staff Mechanical Engineer, Precision Motion Control

10x Genomics Inc
United States, California, Pleasanton
6230 Stoneridge Mall Road (Show on map)
Jul 25, 2025

About The Role

We are seeking an expert and thought leader to join our Hardware Engineering group as a Staff Mechanical Engineer. This role is focused on the mastery of precision motion control, requiring deep, hands-on expertise in control systems theory and servo tuning to achieve nano-scale resolution for our next-generation instruments.

You will take on full leadership of critical projects, guiding the development of cutting-edge mechanical technologies. You will have significant influence on the strategy and execution of complex mechatronic systems, from architecture to the finest details of servo loop optimization. As a key leader, you will not only drive the design of novel systems but also play a central role in mentoring and developing our engineering team in the art and science of precision motion.

What You Will Be Doing



  • Strategic & Technical Leadership: Architect and lead the end-to-end design of novel, large-scale mechatronic systems, including the nano-precision motion and robotics subsystems that are central to our instruments.
  • Advanced Motion Control & Tuning: Lead the hands-on characterization and tuning of complex motion systems. This includes optimizing multi-axis gantry systems and linear stages by expertly tuning PID, servo, and current loops to achieve demanding performance goals.
  • System Analysis & Optimization: Apply control systems theory to diagnose and solve complex motion challenges. You will be responsible for analyzing system performance and stability using tools like Bode plots, ensuring appropriate phase and gain margins for robust, high-speed, and nano-scale resolution moves.
  • Execution & Integration: Lead cross-functional teams (Electrical, Software, Biology, NPI) to ensure the seamless integration of your motion systems. Drive projects from concept, through rigorous testing and validation, into manufacturing and deployment.
  • Mentorship & Team Growth: Mentor junior and mid-level engineers in the principles of advanced motion control. Act as the team's subject matter expert, fostering a culture of innovation, collaboration, and deep technical understanding.
  • Vendor & Partner Management: Lead technical collaboration with motion control vendors to develop and specify custom-designed products, ensuring optimal performance, cost, and development time for critical components.


To Be Successful, You Will Need



  • A PhD or Master's degree in Mechanical Engineering, Mechatronics, or a related field, with 10+ years of experience in life science instrumentation, semiconductor equipment, and/or automation/robotics.
  • Expert-level, hands-on knowledge of control systems theory and application, including the tuning of PID/servo loops (current, velocity, position), phase/gain margin analysis, and system characterization using Bode plots.
  • Demonstrated experience tuning multi-axis gantry systems and precision linear stages to achieve micro to nano-scale resolution, stability, and move-and-settle times.
  • A proven track record of taking multiple complex products from concept through high-volume manufacturing.
  • Deep experience with programming, configuring, and performance tuning of advanced motion controllers for synchronous, multi-axis trajectories.
  • High proficiency in 3D CAD (SolidWorks preferred) and applying advanced simulation tools (e.g., FEA for structural, thermal, and vibration analysis).
  • Experience with analysis tools such as Python or MATLAB for data acquisition and control system analysis.
  • Excellent communication skills, with the ability to present complex technical information and strategic recommendations to both engineering teams and senior leadership.


Nice to Have



  • Direct experience managing or formally mentoring other engineers.
  • Proficiency with SolidWorks PDM/EPDM and creating detailed mechanical drawings and GD&T.
  • Deep knowledge of design for a variety of manufacturing techniques, including injection molding, machining, casting, and sheet metal.
  • Knowledge of software programming (C++, Java) or electrical engineering design principles.


Below is the base pay range for this full-time position. The actual base pay will depend on several factors unique to each candidate, including one's skills, qualifications, and experience. At 10x, base pay is also just one component of the Company's total compensation package. This role is also eligible for 10x's equity grants, its comprehensive health and retirement benefit programs, and its annual bonus program or sales incentive program. During the hiring process, your 10x recruiter can share more about the Company's total compensation package.

Pay Range
$176,800 $239,200 USD

About 10x Genomics

At 10x Genomics, accelerating our understanding of biology is more than a mission for us. It is a commitment. This is the century of biology, and the breakthroughs we make now have the potential to change the world.

We enable scientists to advance their research, allowing them to address scientific questions they did not even know they could ask. Our tools have enabled fundamental discoveries across biology including cancer, immunology, and neuroscience.

Our teams are empowered and encouraged to follow their passions, pursue new ideas, and perform at their best in an inclusive and dynamic environment. We know that behind every scientific breakthrough, there is a deep infrastructure of talented people driving the life sciences industry and making it possible for scientists and clinicians to make new strides. We are dedicated to finding the very best person for every aspect of our work because the innovations and discoveries that we enable together will lead to better technologies, better treatments, and a better future. Find out how you can make a 10x difference.

Individuals seeking employment at 10x Genomics are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation,or any other characteristic protected by applicable law.

10x does not accept unsolicited applicants submitted by third-party recruiters or agencies. Any resume or application submitted to 10x without a vendor agreement in place will be considered unsolicited and property of 10x, and 10x will not pay a placement fee.

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