Research Techinican - Cancer Center

Massachusetts General Hospital
United States, Massachusetts, Boston
149 13th Street (Show on map)
Jan 07, 2025
The Hata Lab in the Massachusetts General Hospital Cancer Center is seeking a highly motivated individual with a strong scientific background for a full-time laboratory research technician position. Research within the Hata Lab focuses on discovering mechanisms of drug resistance in lung cancer patients treated with targeted therapies and developing new therapies to overcome them. The position available is part of a model development team whose primary goal is to generate and characterize novel lung cancer cell line and mouse models from clinical tumor biopsies. These "first-of-a-kind" lung cancer models comprise the major discovery platform for projects throughout the lab and have enabled numerous therapeutic advances in the clinic. Generation of patient-derived cell lines from clinical tumor biopsy samples Processing clinical tumor and blood samples Aseptic mammalian cell culture technique, including cell line maintenance, cryopreservation, etc. Microscopy Basic molecular biology including DNA isolation and PCR Cell viability and apoptosis assays Generation of patient-derived xenograft (PDX) mouse models from clinical tumor biopsy samples Implantation and serial propagation of lung tumors in immunocompromised mice. Treating tumor-bearing mice with targeted therapies and assessing tumor response Coordination with clinical research staff for clinical tumor sample procurement Organization and maintenance of written and electronic records of samples, experimental procedures and data generated Generation and interpretation of experimental results Participation in weekly lab meetings and joint translation project meetings with laboratory and clinical project teams Responsibility for ordering common laboratory reagents and general lab maintenance PREFERRED EDUCATION AND EXPERIENCE: Bachelors of Science or similar degree in biological sciences Prior laboratory research experience withdemonstrated competence in research techniques and methodologies Evidence or prior demonstration of leadership and organizational skills Proficiency in Microsoft Word, Powerpoint, and Excel SKILLS/ABILITIES/COMPETENCIES REQUIRED: The Research Technician should also possess: Analytical skills and the ability to resolve problems Ability to interpret acceptability of data results Attention to detail in experimental techniques and record-keeping Working knowledge of data management programs Excellent verbal and written communication skills Capable of working independently and as part of a team The Research Technician should also possess: Analytical skills and the ability to resolve problems Ability to interpret acceptability of data results Attention to detail in experimental techniques and record-keeping Working knowledge of data management programs Excellent verbal and written communication skills Capable of working independently and as part of a team The General Hospital Corporation is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.